Christenson ES*, Ho WJ*, Shu D, Durham JN, Brancati M, Davis Bruning H, Petrie S, Wang H, Lu J, Bever KM, Laheru D, De Jesus-Acosta A, Browner I, Donehower R, Pishvaian MJ, Azad N, Zhu Q, Valentin A, Suresh Babu J, Hernandez A, Apostol G, Gao Y, Llosa N, Housseau F, Pardoll D, Jaffee EM, Anders R#, Le DT#.
*co-first; #co-corresponding
Nivolumab and Relatlimab for the treatment of patients with unresectable or metastatic mismatch repair proficient colorectal cancer
Lyman MR*, Mitchell JT*, Raghavan S, Kagohara LT, Huff AL, Haldar SD, Shin SM, Guinn S, Barrett B, Longway G, Hernandez A, Coyne EM, Yuan X, Andaloori L, Lai J, Liu YZ, Karchin R, Gupta A, Kiemen AL, Forjaz A, Wirtz D, Wu PH, Deshpande A, Lee JW, Armstrong TD, Azad NS, Zimmerman JW, Wood LD, Anders RA, Thompson ED, Jaffee EM#, Fertig EJ#, Ho WJ#, Zaidi N#.
*co-first; #co-corresponding
Spatial Proteomics and Transcriptomics Reveal Early Immune Cell Organization in Pancreatic Intraepithelial Neoplasia
Kao C*, Charmsaz S*, Tsai HL*, Aziz K, Shu DH, Munjal K, Griffin E, Leatherman JM, Lipson EJ, Ged Y, Hoffman-Censits J, Li HL, Hallab E, Brancati M, Nakazawa M, Alden S, Thoburn C, Gross NE, Hernandez AG, Coyne EM, Kartalia E, Baretti M, Jaffee EM, Bansal S, Tang L, Chandler GS, Mohindra R, Ho WJ#, Yarchoan M#, Zabransky DJ#.
*co-first; #co-corresponding
Nat Commun. 2025 Apr 21;16(1):3531.
Media coverage: Hopkins Newswise ASCO Post
Age-related divergence of circulating immune responses in patients with solid tumors treated with immune checkpoint inhibitors
Kao CJ*, Charmsaz S*, Alden SL, Brancati M, Li HL, Balaji A, Munjal K, Howe K, Mitchell S, Leatherman J, Griffin E, Nakazawa M, Tsai HL, Danilova L, Thoburn C, Gizzi J, Gross NE, Hernandez A, Coyne EM, Shin SM, Babu JS, Apostol GW, Durham J, Christmas BJ, Konig MF, Lipson EJ, Naidoo J, Cappelli LC, Pabani A, Ged Y, Baretti M, Brahmer J, Hoffman-Censits J, Seiwert TY, Garonce-Hediger R, Guha A, Bansal S, Tang L, Jaffee EM, Chandler GS, Mohindra R, Ho WJ#, Yarchoan M#.
*co-first; #co-corresponding
J Clin Invest. 2024 Aug 29; 134(20): e176567.
Media coverage: Hopkins Newswise
Immune-related events in individuals with solid tumors on immunotherapy associate with Th17 and Th2 signatures
Grasset EM#, Deshpande A, Lee JW, Cho Y, Shin SM, Coyne EM, Hernandez A, Yuan X, Zhang Z, Cimino-Mathews A, Ewald AJ, Ho WJ#.
#co-corresponding
Oncogene. 2024 Sep;43(39):2927-2937
Media coverage: AAAS EurekAlert! the Johns Hopkins NewsLetter Hopkins Newswise
Mapping the breast tumor microenvironment: proximity analysis reveals spatial relationships between macrophage subtypes and metastasis-initiating cancer cells
Gross NE*, Zhang Z*, Mitchell JT, Charmsaz S, Hernandez AG, Coyne EM, Shin SM, Vargas Carvajal DC, Sidiropoulos DN, Cho Y, Mo G, Yuan X, Cannon C, Suresh Babu J, Lyman MR, Armstrong T, Kagohara LT, Bever KM, Le DT, Jaffee EM, Fertig EJ, Ho WJ.
*co-first
Phosphodiesterase-5 inhibition collaborates with vaccine-based immunotherapy to reprogram myeloid cells in pancreatic ductal adenocarcinoma
Shin SM, Hernandez A, Coyne E, Munjal K, Gross NE, Charmsaz S, Yuan X, Yang H, Ho WJ.
CyTOF protocol for immune monitoring of solid tumors from mouse models
Sidiropoulos DN, Stein-O'Brien GL, Danilova L, Gross NE, Charmsaz S, Xavier S, Leatherman J, Wang H, Yarchoan M, Jaffee EM, Fertig EJ, Ho WJ.
Integrated T cell cytometry metrics for immune-monitoring applications in immunotherapy clinical trials
Zabransky DJ, Danilova L, Leatherman JM, Lopez-Vidal TY, Sanchez J, Charmsaz S, Gross NE, Shin S, Yuan X, Hernandez A, Yang H, Xavier S, Shu D, Saeed A, Munjal K, Kamdar Z, Kagohara LT, Jaffee EM, Yarchoan M#, Ho WJ#.
#co-corresponding
Profiling of syngeneic mouse HCC tumor models as a framework to understand anti-PD-1 sensitive tumor microenvironments
Ho WJ*, Zhu Q*, Durham J, Popovic A, Xavier S, Leatherman J, Mohan A, Mo G, Zhang S, Gross N, Charmsaz S, Lin D, Quong D, Wilt B, Kamel IR, Weiss M, Philosophe B, Burkhart R, Burns WR, Shubert C, Ejaz A, He J, Deshpande A, Danilova L, Stein-O'Brien G, Sugar EA, Laheru DA, Anders RA, Fertig EJ, Jaffee EM, Yarchoan M.
*co-first
Nat Cancer. 2021 Sep;2(9):891-903.
Media coverage: AAAS EurekAlert! Hopkins Newswise, OncLive, ASCO Post
Neoadjuvant cabozantinib and nivolumab converts locally advanced HCC into resectable disease with enhanced antitumor immunity
Ho WJ*, Croessmann S*, Lin J*, Phyo ZH, Charmsaz S, Danilova L, Mohan AA, Gross NE, Chen F, Dong J, Aggarwal D, Bai Y, Wang J, He J, Leatherman JM, Yarchoan M, Armstrong TD, Zaidi N, Fertig EJ, Denny JC, Park BH#, Zhang ZY#, Jaffee EM#.
*co-first; #co-corresponding
Systemic inhibition of PTPN22 augments anticancer immunity
Ho WJ, Erbe R, Danilova L, Phyo Z, Bigelow E, Stein-O'Brien G, Thomas DL 2nd, Charmsaz S, Gross N, Woolman S, Cruz K, Munday RM, Zaidi N, Armstrong TD, Sztein MB, Yarchoan M, Thompson ED, Jaffee EM#, Fertig EJ#.
#co-corresponding
Genome Biol. 2021 May 13;22(1):154.
Multi-omic profiling of lung and liver tumor microenvironments of metastatic pancreatic cancer reveals site-specific immune regulatory pathways
A global live cell barcoding approach for multiplexed mass cytometry profiling of mouse tumors
Ho WJ, Yarchoan M, Charmsaz S, Munday RM, Danilova L, Sztein MB, Fertig EJ, Jaffee EM.
JCI Insight. 2020 Jan 30;5(2):e132286.
Multipanel mass cytometry reveals anti-PD-1 therapy-mediated B and T cell compartment remodeling in tumor-draining lymph nodes
Other Notable Works
Adrover JM, Han X, Sun L, Fujii T, Sivetz N, Daßler-Plenker J, Evans C, Peters J, He XY, Cannon CD, Ho WJ, Raptis G, Powers RS, Egeblad M. Neutrophils drive vascular occlusion, tumour necrosis and metastasis. Nature. 2025 Jul 16. doi: 10.1038/s41586-025-09278-3. Epub ahead of print. PMID: 40670787.
Baretti M, Danilova L, Durham JN, Betts CB, Cope L, Sidiropoulos DN, Tandurella JA, Charmsaz S, Gross N, Hernandez A, Ho WJ, Thoburn C, Walker R, Leatherman J, Mitchell S, Christmas B, Saeed A, Gaykalova DA, Yegnasubramanian S, Fertig EJ, Coussens LM, Yarchoan M, Jaffee E, Azad NS. Entinostat in combination with nivolumab in metastatic pancreatic ductal adenocarcinoma: a phase 2 clinical trial. Nat Commun. 2024 Nov 12;15(1):9801. doi: 10.1038/s41467-024-52528-7. PMID: 39532835; PMCID: PMC11557583.
Shu DH, Ho WJ, Kagohara LT, Girgis A, Shin SM, Danilova L, Lee JW, Sidiropoulos DN, Mitchell S, Munjal K, Howe K, Bendinelli KJ, Kartalia E, Qi H, Mo G, Montagne J, Leatherman JM, Lopez-Vidal TY, Zhu Q, Huff AL, Yuan X, Hernandez A, Coyne EM, Zaidi N, Zabransky DJ, Engle LL, Ogurtsova A, Baretti M, Laheru D, Durham JN, Wang H, Sunshine JC, Johnston RJ, Deutsch JS, Taube JM, Anders RA, Jaffee EM, Fertig EJ, Yarchoan M. Immunotherapy response induces divergent tertiary lymphoid structure morphologies in hepatocellular carcinoma. Nat Immunol. 2024 Nov;25(11):2110-2123. doi: 10.1038/s41590-024-01992-w. Epub 2024 Oct 25. PMID: 39455893; PMCID: PMC12042221.
Ludford K, Ho WJ, Thomas JV, Raghav KPS, Murphy MB, Fleming ND, Lee MS, Smaglo BG, You YN, Tillman MM, Kamiya-Matsuoka C, Thirumurthi S, Messick C, Johnson B, Vilar E, Dasari A, Shin S, Hernandez A, Yuan X, Yang H, Foo WC, Qiao W, Maru D, Kopetz S, Overman MJ. Neoadjuvant Pembrolizumab in Localized Microsatellite Instability High/Deficient Mismatch Repair Solid Tumors. J Clin Oncol. 2023 Apr 20;41(12):2181-2190. doi: 10.1200/JCO.22.01351. Epub 2023 Jan 9. PMID: 36623241; PMCID: PMC10489404.
Ho WJ, Jaffee EM. Macrophage-Targeting by CSF1/1R Blockade in Pancreatic Cancers. Cancer Res. 2021 Dec 15;81(24):6071-6073. doi: 10.1158/0008-5472.CAN-21-3603. PMID: 34911778; PMCID: PMC9164148.
Alspach E, Chow RD, Demehri S, Guerriero JL, Gujar S, Hartmann FJ, Helmink BA, Hudson WH, Ho WJ, Ma L, Maier BB, Maltez VI, Miller BC, Moran AE, Parry EM, Pillai PS, Rafiq S, Reina-Campos M, Rosato PC, Rudqvist NP, Ruhland MK, Sagiv-Barfi I, Sahu AD, Samstein RM, Schürch CM, Sen DR, Thommen DS, Wolf Y, Zappasodi R. Supporting the Next Generation of Scientists to Lead Cancer Immunology Research. Cancer Immunol Res. 2021 Nov;9(11):1245-1251. doi: 10.1158/2326-6066.CIR-21-0519. Epub 2021 Sep 20. PMID: 34544686; PMCID: PMC9644410.
Ho WJ, Wood LD. Opposing roles of the immune system in tumors. Science. 2021 Sep 17;373(6561):1306-1307. doi: 10.1126/science.abl5376. Epub 2021 Sep 16. PMID: 34529483.
Wu AA, Bever KM, Ho WJ, Fertig EJ, Niu N, Zheng L, Parkinson RM, Durham JN, Onners B, Ferguson AK, Wilt C, Ko AH, Wang-Gillam A, Laheru DA, Anders RA, Thompson ED, Sugar EA, Jaffee EM, Le DT. A Phase II Study of Allogeneic GM-CSF-Transfected Pancreatic Tumor Vaccine (GVAX) with Ipilimumab as Maintenance Treatment for Metastatic Pancreatic Cancer. Clin Cancer Res. 2020 Oct 1;26(19):5129-5139. doi: 10.1158/1078-0432.CCR-20-1025. Epub 2020 Jun 26. PMID: 32591464; PMCID: PMC7541669.
Ho WJ, Jaffee EM, Zheng L. The tumour microenvironment in pancreatic cancer - clinical challenges and opportunities. Nat Rev Clin Oncol. 2020 Sep;17(9):527-540. doi: 10.1038/s41571-020-0363-5. Epub 2020 May 12. PMID: 32398706; PMCID: PMC7442729.